DeLaurier A, Allen S, deFlandre C, Horton M A, Price J S
The Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.
J Comp Pathol. 2002 Aug-Oct;127(2-3):169-77. doi: 10.1053/jcpa.2002.0577.
Feline osteoclastic resorptive lesions (FORL) of the teeth are common in cats, and lead to pain, destruction of the periodontal ligament, and tooth loss. The expression of interleukin (IL)-1 beta and IL-6 mRNA was higher in teeth with FORL than in normal teeth (P<0.01 and P<0.001, respectively), but no such differences were found between pathological and normal gingival tissue samples. There were no differences between teeth affected with FORL and normal teeth in respect of the expression of receptor activator of NF kappa B ligand (RANKL) mRNA or osteoprotegerin (OPG) mRNA. However, OPG mRNA expression was higher in gingival tissue associated with teeth affected with FORL than in normal gingival tissue (P<0.05), whereas the reverse was true of RANKL mRNA expression (P<0.05). OPG mRNA expression was significantly higher in teeth than in femoral and alveolar bone (P<0.001). RANKL and OPG mRNAs were detected in all tissues examined. The data suggest that the elevated expression of IL-l beta and IL-6 mRNA plays a role in the mediation of osteoclast activity in advanced FORL. In contrast, OPG and RANKL do not appear to regulate osteoclasts in advanced disease. The results also suggest that OPG and RANKL mRNA play a role in mediating inflammatory responses in gingival cells, and that OPG has an inhibiting effect on tooth resorption.
猫牙齿的破骨细胞吸收性病变（FORL）在猫中很常见，会导致疼痛、牙周韧带破坏和牙齿脱落。与正常牙齿相比，FORL牙齿中白细胞介素（IL）-1β和IL-6 mRNA的表达更高（分别为P<0.01和P<0.001），但在病理和正常牙龈组织样本之间未发现此类差异。在受FORL影响的牙齿和正常牙齿之间，核因子κB受体活化因子配体（RANKL）mRNA或骨保护素（OPG）mRNA的表达没有差异。然而，与受FORL影响的牙齿相关的牙龈组织中OPG mRNA表达高于正常牙龈组织（P<0.05），而RANKL mRNA表达则相反（P<0.05）。牙齿中的OPG mRNA表达明显高于股骨和牙槽骨（P<0.001）。在所有检测的组织中均检测到RANKL和OPG mRNA。数据表明，IL-1β和IL-6 mRNA表达升高在晚期FORL破骨细胞活性的介导中起作用。相比之下，在晚期疾病中，OPG和RANKL似乎不调节破骨细胞。结果还表明，OPG和RANKL mRNA在介导牙龈细胞炎症反应中起作用，并且OPG对牙齿吸收有抑制作用。
