Alvarez J I, Londoño D P, Alvarez A L, Trujillo J, Jaramillo M M, Restrepo B I
Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín, Colombia.
J Comp Pathol. 2002 Aug-Oct;127(2-3):186-93. doi: 10.1053/jcpa.2002.0579.
Taenia solium cysticerci infect human beings and pigs, causing cysticercosis. In this study the pig was used as a model to characterize the immune response against cysticerci, given the difficulties in analysing the developing immune response in infected human brains. Metacestodes in different stages of viability or degeneration were isolated from the brain, heart and skeletal muscle of naturally infected swine, and the adjacent tissue was examined histologically. The immune response elicited by the cysticerci was classified into four separate stages. In stage I the parasites were surrounded by a thin layer of collagen type I, and by stage II there was a sparse inflammatory infiltrate. In stage III, granuloma formation was evident, and by stage IV the parasite was surrounded by an eosinophil-rich infiltrate and its vesicular membrane had begun to degenerate. The final stage, IV, was detected mainly in the heart but not in the brain. The granulomatous reaction in swine resembled that described previously in human patients, but differed in the abundance of eosinophils, the relative paucity of plasma cells, and the discrete deposition of collagen. These differences were probably due to the fact that in pigs the immune response can be examined earlier than in human patients, in whom sampling is inevitably made at a more chronic stage.
猪带绦虫囊尾蚴可感染人类和猪，引发囊尾蚴病。鉴于分析受感染人脑内正在发展的免疫反应存在困难，本研究以猪作为模型来表征针对囊尾蚴的免疫反应。从自然感染猪的脑、心脏和骨骼肌中分离出处于不同存活或退化阶段的中绦期幼虫，并对相邻组织进行组织学检查。囊尾蚴引发的免疫反应分为四个不同阶段。在第一阶段，寄生虫被一层薄薄的I型胶原包围，到第二阶段出现稀疏的炎性浸润。在第三阶段，肉芽肿形成明显，到第四阶段，寄生虫被富含嗜酸性粒细胞的浸润物包围，其泡状膜开始退化。最后一个阶段，即第四阶段，主要在心脏中检测到，而在脑中未检测到。猪体内的肉芽肿反应与先前在人类患者中描述的相似，但在嗜酸性粒细胞的丰度、浆细胞相对较少以及胶原的离散沉积方面存在差异。这些差异可能是由于在猪中可以比在人类患者中更早地检查免疫反应，在人类患者中采样不可避免地处于更慢性的阶段。
