Anwar Fatma A S, Negm Eman A, Abdelhaseib Maha, Abdel-Maksoud Fatma M, Mohammed Ahmed A, Mohamed Sara Abdel-Aal, Gareh Ahmed, Elbarbary Nady Khairy, El-Khadragy Manal F, Hassan Ehssan Ahmed, Elmahallawy Ehab Kotb
Department of Zoology, Faculty of Science, Assiut University, Assiut 71526, Egypt.
Department of Physiology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt.
Animals (Basel). 2024 Jan 3;14(1):158. doi: 10.3390/ani14010158.
Bovine cysticercosis is categorized as a serious parasitic zoonotic infestation. The infection is mainly caused by the tapeworm , which infects cattle and humans. The larval stage, , is found in the skeletal and cardiac muscles of infected cattle. Despite its potential public health concern, few studies have been conducted on cardiac cysticercosis in Upper Egypt. This study investigates the prevalence, epidemiology, and impact of cardiac cysticercosis in Upper Egypt, emphasizing how histopathological changes in cardiac muscle and physiological parameters might be associated with the infection. From December 2022 to October 2023, a total of 941 animals from Assiut province, Upper Egypt, were slaughtered and their cardiac muscles were examined for the presence of . Cysts were classified as viable or degenerated through macroscopic inspection. The overall prevalence of infected hearts made up 10.8% of the total examined. The highest prevalence rate was in the summer season followed by spring; winter had the lowest infections. The histopathological examination of infected tissues revealed immune cell infiltration around Cysticercus-infected areas. Additionally, Bax immunostaining demonstrated the apoptotic effect of cysticercosis. Regarding the measured physiological parameters, there were non-significant changes in plasma levels of total protein and albumin in cattle infected with cysticercosis compared with control animals. Moreover, there was a significant decrease in total antioxidant capacity (TAC) combined with a significant increase in lipid peroxide (Malondialdehyde) (MDA), troponin T, and lactate dehydrogenase (LDH) activity in infected animals. The present work documented a set of epidemiological and pathological findings, revealing that is a potentially harmful parasite and can cause significant health problems in both cattle and humans.
牛囊尾蚴病被归类为一种严重的寄生性人畜共患感染病。这种感染主要由绦虫引起，绦虫会感染牛和人类。其幼虫阶段，即囊尾蚴，存在于受感染牛的骨骼肌和心肌中。尽管它对公共卫生有潜在影响，但在上埃及，针对心脏囊尾蚴病的研究却很少。本研究调查了上埃及心脏囊尾蚴病的患病率、流行病学及影响，重点关注心肌组织病理学变化和生理参数如何与感染相关联。从2022年12月至2023年10月，对上埃及阿斯尤特省的941头动物进行了屠宰，并检查其心肌中是否存在囊尾蚴。通过肉眼检查将囊肿分类为活的或退化的。受感染心脏的总体患病率占检查总数的10.8%。患病率最高的季节是夏季，其次是春季；冬季感染率最低。对受感染组织的组织病理学检查显示，在囊尾蚴感染区域周围有免疫细胞浸润。此外，Bax免疫染色显示了囊尾蚴病的凋亡作用。关于所测量的生理参数，与对照动物相比，感染囊尾蚴病的牛血浆中总蛋白和白蛋白水平没有显著变化。此外，受感染动物的总抗氧化能力（TAC）显著下降，同时脂质过氧化物（丙二醛）（MDA）、肌钙蛋白T和乳酸脱氢酶（LDH）活性显著增加。本研究记录了一系列流行病学和病理学发现，表明囊尾蚴是一种潜在有害的寄生虫，可在牛和人类中引发严重的健康问题。
