Rilling William S, Drooz Alain
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Room 2803, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
J Vasc Interv Radiol. 2002 Sep;13(9 Pt 2):S259-63. doi: 10.1016/s1051-0443(07)61794-1.
Hepatocellular carcinoma is a challenging disease to treat because of its association with cirrhosis, variable biologic behavior, and variable morphology and because of the variations in local expertise and resources available. The expertise of multiple specialties is required for optimal treatment, which must be individualized. Multidisciplinary and multimodality approaches can be successful for converting patients with unresectable disease into surgical candidates and can stabilize disease as patients await liver transplantation. Regional and local ablation treatment strategies provide effective palliation and possibly prolong survival in nonsurgical candidates, with novel combinations of therapies showing promising results. Interventional radiologists can and should play a lead role in the multidisciplinary management of this disease and in the development of future treatment strategies.
肝细胞癌是一种治疗颇具挑战性的疾病，原因在于它与肝硬化相关联，具有多变的生物学行为和形态，且各地的专业技术水平和可用资源存在差异。最佳治疗需要多个专业的专业知识，且必须因人而异。多学科和多模式方法对于将无法切除的疾病患者转变为手术候选者可能会取得成功，并且在患者等待肝移植期间可以稳定病情。区域和局部消融治疗策略可为非手术候选者提供有效的姑息治疗，并可能延长生存期，新的联合治疗方法显示出了有前景的结果。介入放射科医生能够且应该在这种疾病的多学科管理以及未来治疗策略的制定中发挥主导作用。
