Kalman D, Incledon T, Gaunaurd I, Schwartz H, Krieger D
Miami Research Associates, Miami, Florida 33143, USA.
Int J Obes Relat Metab Disord. 2002 Oct;26(10):1363-6. doi: 10.1038/sj.ijo.0802061.
This study was undertaken to determine the acute effects of a commercial weight loss supplement containing herbal ephedrine and caffeine on cardiovascular function in healthy overweight adults.
Randomized double blind clinical trial evaluating the cardiovascular effects of an ephedra-caffeine (Xenadrine(TM); XEN) based herbal product vs placebo (PLA).
Twenty-seven healthy overweight adults (age 21-60 y; body mass index > or = 25 kg/m(2)).
Systolic and diastolic blood pressure, heart rate, serial electrocardiograms (EKG) and Doppler echocardiograms.
A comparison of means between the groups indicated no statistically significant differences at the start of the study for the variables above. There were no serious adverse events. When examining the effects of XEN vs PLA on cardiovascular health/function, there were no significant effects observed in heart rate, systolic blood pressure, diastolic blood pressure, left ventricular ejection fraction, heart valve function or in cardiovascular physiology within the parameters measured.
These findings indicate that, over a 14-day period, ingestion of the commercial weight loss supplement in a healthy overweight population did not produce any noticeable cardiovascular side effects.
本研究旨在确定一种含有草药麻黄碱和咖啡因的商业减肥补充剂对健康超重成年人心血管功能的急性影响。
随机双盲临床试验，评估基于麻黄碱 - 咖啡因（Xenadrine™；XEN）的草药产品与安慰剂（PLA）对心血管的影响。
27名健康超重成年人（年龄21 - 60岁；体重指数≥25 kg/m²）。
收缩压和舒张压、心率、系列心电图（EKG）和多普勒超声心动图。
两组之间的均值比较表明，在研究开始时，上述变量无统计学显著差异。未出现严重不良事件。在检查XEN与PLA对心血管健康/功能的影响时，在所测量参数范围内，心率、收缩压、舒张压、左心室射血分数、心脏瓣膜功能或心血管生理方面均未观察到显著影响。
这些发现表明，在14天的时间里，健康超重人群摄入该商业减肥补充剂未产生任何明显的心血管副作用。
