Ishio Tetsuya, Kohnoe Shunji, Endo Kazuya, Yamamoto Manabu, Ikeda Yasuharu, Toh Yasushi, Baba Hideo, Okamura Takeshi, Kawamoto Kenji
Dept. of Gastrointestinal Surgery, National Kyushu Cancer Center.
Gan To Kagaku Ryoho. 2002 Sep;29(9):1627-30.
A 56-year-old man presented with dysphagia, and was found to have a type 3 advanced gastric cancer with bilateral multiple lung metastases. This patient was treated with low-dose 5-FU plus CDDP chemotherapy. In the first course, CDDP (6 mg/m2/day) plus 5-FU (300 mg/m2/day) were infused for 5 successive days a week, but a tumor response was not achieved. Therefore, in the second course, CDDP (6 mg/m2/day) plus 5-FU (600 mg/m2/day) were infused every other day (3 days a week). In response to the treatment, both the gastric tumor and the lung metastases almost completely disappeared (reduction rate 95%), and PR was achieved. The CEA level markedly decreased, from 260.3 to 1.4 ng/ml and the patient's symptoms disappeared. Following this treatment, low-dose CDDP plus UFT therapy was performed and the PR was maintained for 12 months. This report shows a case of advanced gastric cancer that responded to low-dose 5-FU plus CDDP.
一名56岁男性因吞咽困难就诊，被诊断为3型进展期胃癌伴双侧多发肺转移。该患者接受了低剂量5-氟尿嘧啶联合顺铂化疗。在第一个疗程中，顺铂（6mg/m²/天）加5-氟尿嘧啶（300mg/m²/天）每周连续输注5天，但未获得肿瘤反应。因此，在第二个疗程中，顺铂（6mg/m²/天）加5-氟尿嘧啶（600mg/m²/天）每隔一天（每周3天）输注。作为对治疗的反应，胃肿瘤和肺转移灶几乎完全消失（缩小率95%），达到部分缓解（PR）。癌胚抗原（CEA）水平显著下降，从260.3降至1.4ng/ml，患者症状消失。在此治疗后，进行了低剂量顺铂加优福定治疗，部分缓解维持了12个月。本报告展示了一例对低剂量5-氟尿嘧啶联合顺铂有反应的进展期胃癌病例。
