中药与干扰素治疗慢性乙型肝炎：随机对照试验的荟萃分析。
Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: a meta-analysis of randomized, controlled trials.
作者信息
McCulloch Michael, Broffman Michael, Gao Jin, Colford John M
机构信息
Pine Street Clinic, San Anselmo, CA, USA.
出版信息
Am J Public Health. 2002 Oct;92(10):1619-28. doi: 10.2105/ajph.92.10.1619.
OBJECTIVES
This meta-analysis was conducted to examine the effectiveness of Chinese herbal medicine (either alone or with interferon alfa) in treating chronic hepatitis B.
METHODS
We searched the TCMLARS, AMED, CISCOM, EMBASE, MEDLINE, and Cochrane Collaboration databases and then hand-searched the articles' bibliographies.
RESULTS
Chinese herbal medicine significantly increased seroreversion of HBsAg and was equivalent to interferon alfa in seroreversion of HBeAg and hepatitis B virus (HBV) DNA; Chinese herbal medicine combined with interferon alfa significantly increased seroreversion of HBsAg, HBeAg, and HBV DNA. The Chinese herbal medicine active component bufotoxin combined with interferon alfa significantly increased HBeAg and HBV DNA seroreversion. The Chinese herbal medicine active component kurorinone was equivalent to interferon alfa in seroreversion of HBeAg and HBV DNA.
CONCLUSIONS
Although the quality of existing studies was poor, these data suggest that further trials of Chinese Herbal Medicine and interferon in chronic hepatitis B infection are justified.
目的
进行此项荟萃分析以检验中药（单独使用或与干扰素α联合使用）治疗慢性乙型肝炎的有效性。
方法
我们检索了中国中医药数据库、亚洲医学索引、补充与替代医学数据库、荷兰医学文摘数据库、医学期刊数据库以及考克兰协作网数据库，随后人工检索了这些文章的参考文献。
结果
中药显著提高了乙肝表面抗原的血清学转阴率，并且在乙肝e抗原和乙肝病毒（HBV）DNA的血清学转阴率方面与干扰素α相当；中药与干扰素α联合使用显著提高了乙肝表面抗原、乙肝e抗原和乙肝病毒DNA的血清学转阴率。中药活性成分蟾毒素与干扰素α联合使用显著提高了乙肝e抗原和乙肝病毒DNA的血清学转阴率。中药活性成分kurorinone在乙肝e抗原和乙肝病毒DNA的血清学转阴率方面与干扰素α相当。
结论
尽管现有研究质量较差，但这些数据表明进一步开展中药与干扰素治疗慢性乙型肝炎感染的试验是合理的。
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