Miranda Jamilette, McConnell Rob, Delgado Edgar, Cuadra Ricardo, Keifer Matthew, Wesseling Catharina, Torres Edmundo, Lundberg Ingvar
Department of Physiology, National Autonomous University, Léon, Nicaragua.
Int J Occup Environ Health. 2002 Jul-Sep;8(3):212-9. doi: 10.1179/107735202800338876.
This study evaluated the association between acute poisoning with organophosphate pesticides (OPs) and quantitative tactile vibration thresholds. Thresholds of the dominant index fingers and big toes of 56 men hospitalized for acute poisoning with OPs were measured at hospital discharge (1-24 days after poisoning) and around seven weeks later (24-176 days after poisoning), and compared with those of controls. Thresholds of the big toes of men with severe intentional poisonings due to neuropathic OPs (metamidophos and chlorpyrifos) increased between the first and second examinations. Threshold impairment was not detected in the index finger regardless of poisoning agent or severity. The development of threshold impairment as a consequence of severe intentional poisonings with neuropathic OPs is consistent with other reports indicating that only severe OP poisonings produce sensory peripheral nerve effects.
本研究评估了有机磷农药（OPs）急性中毒与定量触觉振动阈值之间的关联。对56名因OPs急性中毒住院的男性，在出院时（中毒后1 - 24天）和大约七周后（中毒后24 - 176天）测量其优势食指和大脚趾的阈值，并与对照组进行比较。因神经性OPs（甲胺磷和毒死蜱）导致严重故意中毒的男性，其大脚趾的阈值在第一次和第二次检查之间有所增加。无论中毒剂或严重程度如何，食指均未检测到阈值损害。因神经性OPs严重故意中毒导致阈值损害的情况与其他报告一致，这些报告表明只有严重的OP中毒才会产生感觉性周围神经效应。
