Masuda Toshiya, Inaba Yuzuru, Maekawa Tomomi, Takeda Yoshio, Tamura Hirotoshi, Yamaguchi Hidemasa
Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770-8502, Japan.
J Agric Food Chem. 2002 Oct 9;50(21):5863-9. doi: 10.1021/jf025605o.
A solution of carnosic acid quinone, which is a radical chain-termination product having no antioxidant activity in the antioxidant reaction of carnosic acid, recovers potent antioxidant activity upon standing. The HPLC analysis of an aged solution of carnosic acid quinone revealed that several antioxidants are produced in the solution. From the time-course and quantitative analyses of the formation of the products and their structural analysis, an antioxidant mechanism from carnosic acid quinone is proposed that includes a redox reaction of carnosic acid quinone in addition to the isomerization to lactone derivatives. In the first stage of antioxidation, carnosic acid, the reduction product from carnosic acid quinone, contributes to the potent antioxidant activity of the solution. This proposed mechanism can explain one of the reasons for the strong antioxidant activity of the extract of the popular herbs sage and rosemary.
鼠尾草酸醌溶液在鼠尾草酸的抗氧化反应中是一种没有抗氧化活性的自由基链终止产物，但静置后能恢复强大的抗氧化活性。对老化的鼠尾草酸醌溶液进行的高效液相色谱分析表明，该溶液中会产生几种抗氧化剂。通过对产物形成的时间进程和定量分析以及它们的结构分析，提出了一种鼠尾草酸醌的抗氧化机制，该机制除了异构化为内酯衍生物外，还包括鼠尾草酸醌的氧化还原反应。在抗氧化的第一阶段，鼠尾草酸醌的还原产物鼠尾草酸对溶液强大的抗氧化活性有贡献。这一提出的机制可以解释流行草药鼠尾草和迷迭香提取物具有强大抗氧化活性的原因之一。
