Imamura Toshihiko, Morimoto Akira, Takanashi Mami, Hibi Shigeyoshi, Sugimoto Tohru, Ishii Eiichi, Imashuku Shinsaku
Department of Paediatrics, Kyoto Prefectural University of Medicine, Japan.
Br J Haematol. 2002 Oct;119(1):119-21. doi: 10.1046/j.1365-2141.2002.03803.x.
We studied the expression of HoxA9 and Meis1 by reverse transcriptase-polymerase chain reaction analysis in leukaemic cells from cases of infant acute lymphoblastic leukaemia (ALL, n = 27) and childhood ALL (n = 29). These two genes were co-expressed significantly more frequently in infant ALL than in childhood ALL (19/27 vs0/29 cases, P < 0.001) and were highly associated with MLL gene rearrangement in infant ALL cases (P < 0.001). These findings indicate that the HoxA9 and Meis1 genes are closely associated with MLL gene rearrangement in the development of infant ALL, which represents a distinct entity of childhood ALL.
我们通过逆转录聚合酶链反应分析，研究了27例婴儿急性淋巴细胞白血病（ALL）和29例儿童ALL患者白血病细胞中HoxA9和Meis1的表达情况。这两个基因在婴儿ALL中的共表达频率显著高于儿童ALL（19/27例对比0/29例，P < 0.001），并且在婴儿ALL病例中与MLL基因重排高度相关（P < 0.001）。这些发现表明，HoxA9和Meis1基因在婴儿ALL的发生发展中与MLL基因重排密切相关，婴儿ALL是儿童ALL的一个独特亚型。
