Linneberg A, Henrik Nielsen N, Frølund L, Madsen F, Dirksen A, Jørgensen T
Department of Internal Medicine M, Centre for Preventive Medicine, Glostrup University Hospital, 57 Ndr. Ringvej, Entrance 8, 7th Floor, DK-2600 Glostrup, Denmark.
Allergy. 2002 Nov;57(11):1048-52. doi: 10.1034/j.1398-9995.2002.23664.x.
It has been hypothesized that allergic rhinitis and allergic asthma are manifestations of the same disease entity. We aimed to investigate the relationship between allergic rhinitis and allergic asthma.
Participants in a population-based study of 15-69-year-olds in 1990 were invited to a follow-up in 1998. A total of 734 subjects were examined on two occasions eight years apart. Allergic rhinitis to pollen was defined as a history of nasal symptoms on exposure to pollens and IgE specific to pollen. Allergic asthma to pollen was defined as a history of lower airway symptoms on exposure to pollens and IgE specific to pollen. Similarly, diagnoses of allergic rhinitis and allergic asthma to animals or mite were defined.
At follow-up, all subjects with allergic asthma to pollen (n = 52) had in addition allergic rhinitis to pollen. In the longitudinal analysis, there were a total of 28 new (incident) cases of allergic asthma to pollen. They all had allergic rhinitis to pollen at baseline, or had developed allergic rhinitis to pollen at follow-up. Accordingly, allergic rhinitis to animals and mite were ubiquitous in subjects with allergic asthma to animals and mite, respectively.
The results support the hypothesis that allergic rhinitis and allergic asthma are manifestations of the same disease entity.
据推测，变应性鼻炎和变应性哮喘是同一疾病实体的表现形式。我们旨在研究变应性鼻炎与变应性哮喘之间的关系。
1990年对15至69岁人群进行的一项基于人群的研究中的参与者被邀请在1998年进行随访。共有734名受试者在相隔八年的两个时间点接受检查。对花粉的变应性鼻炎定义为接触花粉时出现鼻部症状的病史以及对花粉的特异性IgE。对花粉的变应性哮喘定义为接触花粉时出现下呼吸道症状的病史以及对花粉的特异性IgE。同样，对动物或螨的变应性鼻炎和变应性哮喘的诊断也有明确界定。
在随访时，所有对花粉有变应性哮喘的受试者（n = 52）均同时患有对花粉的变应性鼻炎。在纵向分析中，共有28例新发（初发）对花粉的变应性哮喘病例。他们在基线时均患有对花粉的变应性鼻炎，或在随访时出现了对花粉的变应性鼻炎。相应地，对动物和螨有变应性哮喘的受试者中，对动物和螨的变应性鼻炎也普遍存在。
这些结果支持变应性鼻炎和变应性哮喘是同一疾病实体的表现形式这一假说。
