伴有继发性精神病性症状的创伤后应激障碍的家族史研究。
Family history study of posttraumatic stress disorder with secondary psychotic symptoms.
作者信息
Sautter Frederic J, Cornwell John, Johnson Janet J, Wiley Justin, Faraone Stephen V
机构信息
South Central Mental Illness Research Education and Clinical Center, New Orleans, LA, USA.
出版信息
Am J Psychiatry. 2002 Oct;159(10):1775-7. doi: 10.1176/appi.ajp.159.10.1775.
OBJECTIVE
A family history approach was used to determine if posttraumatic stress disorder (PTSD) with secondary psychotic symptoms was associated with a familial vulnerability to schizophrenia and other psychoses.
METHOD
Family history methods were used to compare rates of familial psychopathology in the first-degree relatives of three proband groups: 1) patients with DSM-IV PTSD with secondary psychotic symptoms, 2) patients with DSM-IV PTSD without psychotic symptoms, and 3) healthy matched comparison subjects.
RESULTS
PTSD with secondary psychotic symptoms was not associated with an excess of familial psychotic disorder but was associated with a higher morbid risk for depression.
CONCLUSIONS
PTSD with secondary psychotic symptoms was not associated with familial psychosis, suggesting it does not reflect the presence of an underlying psychotic disorder.
目的
采用家族史研究方法来确定伴有继发性精神病性症状的创伤后应激障碍（PTSD）是否与家族性精神分裂症及其他精神病易感性相关。
方法
运用家族史研究方法比较三组先证者一级亲属的家族精神病理学发生率：1）患有DSM-IV中伴有继发性精神病性症状的PTSD患者；2）患有DSM-IV中无精神病性症状的PTSD患者；3）健康匹配对照者。
结果
伴有继发性精神病性症状的PTSD与家族性精神病性障碍增多无关，但与更高的抑郁症发病风险相关。
结论
伴有继发性精神病性症状的PTSD与家族性精神病无关，提示其并不反映潜在的精神病性障碍的存在。
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