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强迫症与5-羟色胺（1Dβ）受体基因之间无关联。

No association between obsessive-compulsive disorder and the 5-HT(1Dbeta) receptor gene.

作者信息

Di Bella Daniela, Cavallini Maria Cristina, Bellodi Laura

机构信息

Department of Neuropsychiatric Services, Vita-Salute University, Fondazione Centro San Raffaele del Monte Tabor, Via Stamira d'Ancona 20, 20127 Milan, Italy.

出版信息

Am J Psychiatry. 2002 Oct;159(10):1783-5. doi: 10.1176/appi.ajp.159.10.1783.

DOI:10.1176/appi.ajp.159.10.1783
PMID:12359689
Abstract

OBJECTIVE

Serotonin abnormalities may be involved in the etiopathogenesis of obsessive-compulsive disorder (OCD). The silent G-to-C substitution at nucleotide 861 of the coding region of the 5-HT(1Dbeta) receptor gene may be associated with liability to OCD. The aim of this study was to investigate this association in an Italian OCD study group.

METHOD

Genotyping for 5-HT(1Dbeta) was performed for 79 nuclear families of probands with OCD. The transmission/disequilibrium test was used to determine transmission of the alleles from parents to offspring.

RESULTS

Of the 79 families, 48 were informative for the analysis, i.e., both parents were genotyped for 5-HT(1Dbeta), and at least one parent was heterozygous. No preferential transmission of either allele of the 5-HT(1Dbeta) gene was observed.

CONCLUSIONS

These data do not support a role for the 5-HT(1Dbeta) receptor gene in conferring susceptibility to OCD.

摘要

目的

血清素异常可能参与强迫症（OCD）的病因发病机制。5-HT(1Dβ)受体基因编码区第861位核苷酸的沉默G到C替换可能与患OCD的易感性有关。本研究的目的是在一个意大利OCD研究组中调查这种关联。

方法

对79个患有OCD的先证者核心家庭进行5-HT(1Dβ)基因分型。传递/不平衡检验用于确定等位基因从父母到后代的传递情况。

结果

在79个家庭中，48个家庭可用于分析，即父母双方都进行了5-HT(1Dβ)基因分型，且至少有一位父母是杂合子。未观察到5-HT(1Dβ)基因的任何一个等位基因有优先传递现象。

结论

这些数据不支持5-HT(1Dβ)受体基因在赋予OCD易感性方面起作用。

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