Camarena Beatriz, Aguilar Alejandro, Loyzaga Cristina, Nicolini Humberto
Departamento de Genética Psiquiátrica, Instituto Nacional de Psiquiatría Ramón de la Fuente, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Mexico D.F., 14370, México.
Int J Neuropsychopharmacol. 2004 Mar;7(1):49-53. doi: 10.1017/S1461145703003869. Epub 2004 Jan 20.
Pharmacological studies have shown that sumatriptan, a selective ligand of the serotonin 5-HT-1Dbeta autoreceptor, modifies obsessive-compulsive disorder (OCD) symptoms. The current study analysed the G861C polymorphism of the 5-HT-1Dbeta gene in a sample of 72 trios. Genotyping data were analysed using the Family-Based Association Test (FBAT). We did not replicate the previously reported linkage disequilibrium between the G861 variant and OCD. However, a quantitative trait analysis, assessing severity of OCD symptoms and defined as YBOCS score, confirmed the finding that subjects with a preferential transmission of the G861 variant showed higher YBOCS Obsession scores compared to patients carrying the C861 allele. These preliminary findings may indicate that the 5-HT-1Dbeta receptor gene could be involved in the severity of obsession symptoms in OCD. However, it is important to perform the replication of these findings in larger sample sizes of informative families.
药理学研究表明，舒马曲坦作为5-羟色胺5-HT-1Dβ自身受体的选择性配体，可改善强迫症（OCD）症状。本研究分析了72个三联体样本中5-HT-1Dβ基因的G861C多态性。使用基于家系的关联检验（FBAT）分析基因分型数据。我们没有重复先前报道的G861变体与强迫症之间的连锁不平衡。然而，一项评估强迫症症状严重程度（定义为耶鲁布朗强迫症量表（YBOCS）评分）的数量性状分析证实了以下发现：与携带C861等位基因的患者相比，优先传递G861变体的受试者表现出更高的YBOCS强迫观念评分。这些初步发现可能表明，5-HT-1Dβ受体基因可能与强迫症强迫观念症状的严重程度有关。然而，在更多信息丰富的家系大样本中重复这些发现很重要。
