van der Kleij Desiree, Latz Eicke, Brouwers Jos F H M, Kruize Yvonne C M, Schmitz Marion, Kurt-Jones Evelyn A, Espevik Terje, de Jong Esther C, Kapsenberg Martien L, Golenbock Douglas T, Tielens Aloysius G M, Yazdanbakhsh Maria
Department of Parasitology, Leiden University Medical Center, The Netherlands.
J Biol Chem. 2002 Dec 13;277(50):48122-9. doi: 10.1074/jbc.M206941200. Epub 2002 Sep 30.
Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology.
血吸虫感染的特征是在感染的慢性阶段出现显著的T细胞低反应性。我们发现，血吸虫特异性磷脂酰丝氨酸（PS）激活TLR2并影响树突状细胞，使得成熟的树突状细胞获得了诱导产生白细胞介素-10的调节性T细胞发育的能力。通过质谱分析，血吸虫溶血磷脂酰丝氨酸（lyso-PS）被鉴定为激活TLR2的分子。这种活性似乎是血吸虫lyso-PS的独特特性，其含有特定的酰基链，因为合成的lyso-PS（16:0）和从哺乳动物宿主分离的PS均不能激活TLR2。综上所述，这些发现为一种新的宿主-寄生虫相互作用提供了证据，这种相互作用可能是寄生虫长期存活和有限宿主病理的核心，其影响超出了寄生虫学领域。
