Tompa Peter
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, 1518, PO Box 7, Budapest, Hungary.
Trends Biochem Sci. 2002 Oct;27(10):527-33. doi: 10.1016/s0968-0004(02)02169-2.
The recent suggestion that the classical structure-function paradigm should be extended to proteins and protein domains whose native and functional state is intrinsically unstructured has received a great deal of support. There is ample evidence that the unstructured state, common to all living organisms, is essential for basic cellular functions; thus it deserves to be recognized as a separate functional and structural category within the protein kingdom. In this review, recent findings are surveyed to illustrate that this novel but rapidly advancing field has reached a point where these proteins can be comprehensively classified on the basis of structure and function.
最近有人提出，经典的结构-功能范式应扩展到天然和功能状态本质上无结构的蛋白质和蛋白质结构域，这一观点得到了大量支持。有充分证据表明，所有生物共有的无结构状态对于基本细胞功能至关重要；因此，它理应被视为蛋白质王国中一个独立的功能和结构类别。在这篇综述中，我们调查了最近的研究结果，以说明这个新颖但发展迅速的领域已经发展到可以根据结构和功能对这些蛋白质进行全面分类的阶段。
