Kawaguchi K, Hirai I, Morikawa J, Mochizuki M, Tojo S
Nihon Naibunpi Gakkai Zasshi. 1975 Jun 20;51(6):546-55. doi: 10.1507/endocrine1927.51.6_546.
In order to know the secretory behaviors of human growth hormone (hGH) and human prolactin (hPRL) during pregnancy, the following studies were undertaken. Twenty three normal pregnant women of every period of gestation, eighteen women of postpartum and five nonpregnant subjects volunteered for this study. After fasting overnight, these volunteers were placed at complete bed rest, and a fasting antecubital venous blood sample was drawn at 8:00 a.m. Then L-arginine, 30 g, was infused intravenously over a 30 minute period, and venous blood samples were drawn at 30, 45, 60, 90, 120, minutes after infusion. Serum hGH level was detected by hGH radioimmunoassay Kit (Dainabot) and serum hPRL concentration was measured by double-antibody radioimmunoassay system (NIH-NIAMDD). In addition, serum hCS level was measured by hCS-Kobe double-antibody radioimmunoassay system in comparison with the secretory behaviors of hGH and hPRL. 1. Serum hGH, hPRL and hCS concentrations during pregnancy. HGH concentration remained almost unchanged through the course of pregnancy, but hPRL and hCS concentrations increased with the programs of pregnancy. 2. Serum hGH and hPRL concentrations in puerperium. HGH level did not change as compared to that of nonpregnant or pregnant women. HPRL concentration maintained high level in 1-3 postpartum weeks. 3. Effect of arginine on the concentrations of serum hGH, hPRL and hCS during pregnancy. The hGH response decreased, but that of hPRL increased along with the progress of pregnancy. During the arginine loading test there was no significant change in hCS concentration. 4. Effect of arginine on the concentrations of serum hGH and hPRL in puerperium. The HGH response was suppressed at the first week of the postpartum. The response of hPRL was lower than that of late pregnancy. To summarize, hGH and hPRL have some similar biological characters, but there was a difference in secretion pattern of the two hormones during pregnancy. Reserve function of hGH secretion was suppressed, but that of hPRL secretion increased along with the progress of pregnancy. And in the third trimester of pregnancy, the difference of the secretory behavior and secretory reserve function between hGH and hPRL was prominent.
为了解妊娠期间人生长激素（hGH）和人催乳素（hPRL）的分泌情况，进行了以下研究。23名处于妊娠各期的正常孕妇、18名产后妇女和5名非孕妇自愿参与本研究。这些志愿者隔夜禁食后，完全卧床休息，于上午8点采集空腹肘前静脉血样本。然后在30分钟内静脉输注30克L-精氨酸，并在输注后30、45、60、90、120分钟采集静脉血样本。采用hGH放射免疫分析试剂盒（Dainabot）检测血清hGH水平，采用双抗体放射免疫分析系统（NIH-NIAMDD）测定血清hPRL浓度。此外，采用hCS-神户双抗体放射免疫分析系统测量血清hCS水平，并与hGH和hPRL的分泌情况进行比较。1. 妊娠期间血清hGH、hPRL和hCS浓度。hGH浓度在妊娠过程中几乎保持不变，但hPRL和hCS浓度随妊娠进程而升高。2. 产褥期血清hGH和hPRL浓度。与非孕妇或孕妇相比，hGH水平无变化。hPRL浓度在产后1-3周维持在高水平。3. 精氨酸对妊娠期间血清hGH、hPRL和hCS浓度的影响。随着妊娠进展，hGH反应降低，但hPRL反应升高。在精氨酸负荷试验期间，hCS浓度无显著变化。4. 精氨酸对产褥期血清hGH和hPRL浓度的影响。产后第一周hGH反应受到抑制。hPRL反应低于妊娠晚期。综上所述，hGH和hPRL具有一些相似的生物学特性，但在妊娠期间这两种激素的分泌模式存在差异。hGH分泌的储备功能受到抑制，但hPRL分泌的储备功能随妊娠进展而增强。并且在妊娠晚期，hGH和hPRL在分泌行为和分泌储备功能上的差异较为突出。
