Bellmann O, Bröschen-Zywietz C
Z Geburtshilfe Perinatol. 1978 Apr;182(2):105-12.
There is little information to what extent the secretion of prolactin (HPRL) can be stimulated in pregnancy. The effect of thyrotropin releasing hormone (TRH) on the secretion of HPRL and thyroid stimulating hormone (TSH) in late pregnancy was examined with special emphasis on the amount and time sequence of secretion of both hormones. 21 pregnant women and 20 non-pregnant women were tested by intravenous injection of 200 ug TRH. In the pregnant group the HPRL serum levels increased much more than in the non-pregnant group, however, the increase of HPRL above baseline levels expressed as percentage was lower. In contrast, TSH secretion was similar in both groups. The baseline levels of HPRL did not influence the response to the stimulus. There was no evidence for a correlation between the secretion of HPRL and TSH. The maximal increase of both hormones in serum occurred at various testpoints, however, most of the HPRL peaks preceded those of TSH. Repeating the TRH test after two or three days resulted in good reproducibility concerning HPRL secretion whereas TSH secretion was diminished.
关于孕期催乳素（HPRL）分泌能在多大程度上受到刺激的信息很少。研究了促甲状腺激素释放激素（TRH）对妊娠晚期HPRL和促甲状腺激素（TSH）分泌的影响，特别关注了这两种激素分泌的量和时间顺序。通过静脉注射200微克TRH对21名孕妇和20名非孕妇进行了测试。在孕妇组中，血清HPRL水平的升高比非孕妇组多得多，然而，以百分比表示的HPRL高于基线水平的升高幅度较低。相比之下，两组的TSH分泌相似。HPRL的基线水平不影响对刺激的反应。没有证据表明HPRL和TSH的分泌之间存在相关性。两种激素在血清中的最大升高出现在不同的测试点，然而，大多数HPRL峰值先于TSH峰值出现。在两三天后重复TRH测试，HPRL分泌具有良好的可重复性，而TSH分泌减少。
