烟酰胺在缺血再灌注治疗中的药物化学
Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.
作者信息
Yang J, Klaidman L K, Adams J D
机构信息
School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089, USA.
出版信息
Mini Rev Med Chem. 2002 Apr;2(2):125-34. doi: 10.2174/1389557024605483.
PMID:12370074
Abstract
Nicotinamide can facilitate DNA repair by inhibiting poly(ADP-ribose) polymerase, increasing NAD levels and adjusting other related enzyme activities. This review will summarize recent work on the design of poly(ADP-ribose) polymerase inhibitors, poly(ADP-ribose) glycohydrolase inhibitors and will discuss the possible use of drugs that interact with NAD synthetic enzymes.
摘要
烟酰胺可通过抑制聚（ADP - 核糖）聚合酶、提高烟酰胺腺嘌呤二核苷酸（NAD）水平和调节其他相关酶活性来促进DNA修复。本综述将总结聚（ADP - 核糖）聚合酶抑制剂、聚（ADP - 核糖）糖苷水解酶抑制剂设计方面的近期研究工作，并将讨论与NAD合成酶相互作用的药物的可能用途。
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