Molecular and Integrative Biology Lab (MIB), Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
Department of Internal Medicine, Pusan National University School of Korean Medicine, Yangsan, Korea.
Eur J Clin Invest. 2020 Oct;50(10):e13334. doi: 10.1111/eci.13334. Epub 2020 Jul 22.
Nicotinamide adenine dinucleotide (NAD ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, poly (ADP-ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD . The therapeutic potential of dietarily available NAD boosters preserving the NAD pool has been attracting attention after the discovery of declining NAD levels in ageing model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD , including the salubrious effects of NAD boosters and discuss their future translational strategies.
烟酰胺腺嘌呤二核苷酸（NAD ）是能量代谢中的一种必需代谢物，也是由 sirtuins、多聚（ADP-核糖）聚合酶（PARPs）和 CD38 介导的蛋白脱酰基、蛋白 ADP-核糖基化和环状 ADP-核糖合成等生化反应的辅酶。在真核细胞中，NAD 通过三种不同的途径合成，这为调节 NAD 的生物利用度提供了不同的策略。在衰老模型生物以及几种与年龄相关的疾病（包括心血管代谢和神经退行性疾病）中发现 NAD 水平下降后，饮食中可用的 NAD 增强剂对 NAD 池的保护作用引起了人们的关注。在这里，我们回顾了 NAD 生物学的最新进展，包括 NAD 增强剂的有益作用，并讨论了它们未来的转化策略。
