Tetik Cihangir, Ozer Kagan, Ayhan Suhan, Siemionow Krzysztof, Browne Earl, Siemionow Maria
Department of Orthopedics and Traumatology, Marmara University, Istanbul, Turkey.
Ann Plast Surg. 2002 Oct;49(4):397-403. doi: 10.1097/00000637-200210000-00011.
Three methods of nerve repair involving the epineural sleeve technique were compared with conventional nerve repair using the rat sciatic nerve transection model in four groups. In group 1, the sciatic nerve was repaired using the conventional epineural technique by placing four sutures. In groups 2, 3, and 4, the epineural sleeve technique was combined with two sutures, fibrin glue, and two sutures with fibrin glue, respectively. Functional recovery was evaluated using walking track analysis, limb circumference, and the severity of toe contracture. Diameter of the sciatic nerve fibers, total number of myelinated fibers, diameter of the myelin sheath, and the axon-to-fiber diameter ratio were measured at 12 weeks. The results showed better functional recovery as well as a higher number of myelinated fibers in groups using the epineural sleeve technique compared with conventional technique ( < 0.05). The addition of fibrin glue, however, did not make any significant difference. The epineural sleeve technique was found to be superior when compared with conventional nerve repair, providing faster functional recovery and improved nerve regeneration.
在四组实验中，使用大鼠坐骨神经横断模型，将三种涉及神经外膜套管技术的神经修复方法与传统神经修复方法进行了比较。在第1组中，采用传统的神经外膜技术，通过缝合四针来修复坐骨神经。在第2、3和4组中，神经外膜套管技术分别与两针缝合、纤维蛋白胶以及两针缝合加纤维蛋白胶相结合。使用行走轨迹分析、肢体周长和趾挛缩严重程度来评估功能恢复情况。在12周时测量坐骨神经纤维直径、有髓纤维总数、髓鞘直径以及轴突与纤维直径比。结果显示，与传统技术相比，使用神经外膜套管技术的组功能恢复更好，有髓纤维数量更多（<0.05）。然而，添加纤维蛋白胶并没有产生任何显著差异。与传统神经修复相比，神经外膜套管技术被发现更具优势，能提供更快的功能恢复和更好的神经再生。
