Niklowitz W J
Neurology. 1975 Oct;25(10):927-34. doi: 10.1212/wnl.25.10.927.
Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200 A diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 A) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed.
兔子急性四乙基铅中毒后会出现典型的神经原纤维缠结。通过电子显微镜研究发现，这种缠结在发生水肿性退变的神经元中出现，主要由直径为200埃、长度极长的光滑微管束组成。在16只动物中有2只还能发现一些扭曲微管（周期为800埃）。文中讨论了这些由铅诱导产生的扭曲微管的意义，这种微管是人类早老性痴呆的特征。
