Wadhwa R, Taira K, Kaul S C
Chugai Research Institute for Medical Sciences, Nagai, Ibaraki.
Histol Histopathol. 2002 Oct;17(4):1173-7. doi: 10.14670/HH-17.1173.
Mortalin is a novel member of the hsp70 family of proteins that exhibits a different staining pattern in normal and immortal cells. It was also cloned as glucose regulated protein, GRP75 and peptidebinding protein, PBP74. It has been assigned multiple functions ranging from stress response, intracellular trafficking, antigen processing, control of cell proliferation, differentiation and tumorigenesis. The present article compiles and reviews information on multiple sites and functions of mortalin. In view of its upregulation in many tumors and transcriptional inactivation function of p53, its potential use in biotechnology and biomedicine is discussed.
Mortalin是热休克蛋白70（hsp70）家族的一个新成员，在正常细胞和永生细胞中呈现出不同的染色模式。它也曾被克隆为葡萄糖调节蛋白GRP75和肽结合蛋白PBP74。它具有多种功能，包括应激反应、细胞内运输、抗原加工、细胞增殖控制、分化和肿瘤发生。本文汇编并综述了关于Mortalin多个作用位点和功能的信息。鉴于其在许多肿瘤中的上调以及对p53的转录失活功能，还讨论了其在生物技术和生物医学中的潜在用途。
