Kaul Sunil C, Taira Kazunari, Pereira-Smith Olivia M, Wadhwa Renu
Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
Exp Gerontol. 2002 Oct-Nov;37(10-11):1157-64. doi: 10.1016/s0531-5565(02)00135-3.
Mortalin, also known as mthsp70/PBP74/GRP75, resides in multiple subcellular sites including mitochondria, ER, plasma membrane, cytoplasmic vesicles and cytosol. It is differentially distributed in normal and cancerous cells; the latter, when reverted back to normal phenotype, also show change in mortalin staining pattern similar to normal cells. Depending on its different subcellular niche and binding partner therein, mortalin is expected to perform multiple functions relevant to cell survival, control of proliferation and stress response.
mortalin，也被称为mthsp70/PBP74/GRP75，存在于多个亚细胞位点，包括线粒体、内质网、质膜、细胞质囊泡和细胞质溶胶。它在正常细胞和癌细胞中的分布不同；当癌细胞恢复为正常表型时，其mortalin染色模式也会发生类似于正常细胞的变化。根据其不同的亚细胞定位及其在其中的结合伴侣，预计mortalin会执行与细胞存活、增殖控制和应激反应相关的多种功能。
