Wormser Uri, Sintov Amnon, Brodsky Berta, Amitai Yona, Nyska Abraham
Faculty of Sciences, The Hebrew University, Givat Ram, Jerusalem, Israel.
Toxicol Pathol. 2002 Sep-Oct;30(5):552-8. doi: 10.1080/01926230290105767.
In this study, the protective prophylactic and post-exposure effects of novel topical iodine preparations were demonstrated upon heat- and hydrofluoric acid-induced skin lesions in the haired guinea pig. Prophylactic treatment of thermal bums with a liquid iodine preparation resulted in statistically significant reductions of 39% and 30%, respectively, in acute inflammation and hemorrhage-microscopic dermal parameters indicative of acute tissue damage. A clear trend of iodine-induced reduction in dermal necrosis occurred, and the epidermal healing markers, acanthosis and hyperkeratosis, were increased. Postexposure treatment of thermal burns with an iodine ointment preparation immediately after occurrence also conferred significant therapeutic reduction in parameters of tissue damage such as epidermal ulceration (87%), acute inflammation (58%), and hemorrhage (30%). Gross pathological evaluation showed that prophylactic and postexposure treatments with the liquid iodine preparation significantly reduced the heat-induced ulceration area by 97% and 65%, respectively. In addition, immediate treatment with an ointment iodine formulation significantly decreased the ulceration area by 98%; its tetraglycol vehicle also had a beneficial effect. Postexposure treatment with the iodine ointment proved efficacious upon hydrofluoric acid-induced skin burns. We observed statistically significant reductions of 76% and 68% in ulceration areas at intervals of 5 and 10 minutes between exposure and treatment, whereas a weaker effect was observed at a longer time interval of 15 minutes. Our findings suggest the therapeutic usage of these newly developed iodine preparations for thermally induced and hydrofluoric acid-induced skin burns.
在本研究中，新型局部碘制剂对有毛豚鼠热灼伤和氢氟酸诱导的皮肤损伤显示出预防和暴露后保护作用。用液体碘制剂对热灼伤进行预防性治疗，在急性炎症和出血（指示急性组织损伤的微观真皮参数）方面分别导致具有统计学意义的39%和30%的降低。出现了碘诱导的真皮坏死减少的明显趋势，并且表皮愈合标志物棘皮症和角化过度增加。热灼伤发生后立即用碘软膏制剂进行暴露后治疗，在组织损伤参数如表皮溃疡（87%）、急性炎症（58%）和出血（30%）方面也有显著的治疗性降低。大体病理评估表明，用液体碘制剂进行预防性和暴露后治疗分别使热诱导的溃疡面积显著减少97%和65%。此外，立即用碘软膏配方治疗使溃疡面积显著减少98%；其聚乙二醇 vehicle 也有有益效果。用碘软膏进行暴露后治疗被证明对氢氟酸诱导的皮肤灼伤有效。我们观察到，在暴露和治疗之间间隔5分钟和10分钟时，溃疡面积分别有统计学意义的76%和68%的减少，而在15分钟的较长时间间隔时观察到的效果较弱。我们的研究结果表明，这些新开发的碘制剂可用于治疗热诱导和氢氟酸诱导的皮肤灼伤。
