Dunn B J, MacKinnon M A, Knowlden N F, Billmaier D J, Derelanko M J, Rusch G M, Naas D J, Dahlgren R R
AlliedSignal Inc., Morristown, New Jersey 07962-1139, USA.
J Occup Environ Med. 1996 May;38(5):507-14. doi: 10.1097/00043764-199605000-00011.
Several topical treatments for hydrofluoric acid dermal burns (Zephiran, calcium acetate and magnesium hydroxide antacid soaks, and calcium gluconate gel) were assessed for efficacy in a pig model. Gross appearance and histopathology of treated and untreated burn sites were evaluated. For superficial burns, Zephiran was most effective; calcium acetate, magnesium hydroxide antacid, and calcium gluconate gel were less effective. For deep burns, gross observations showed that calcium acetate and Zephiran were most efficacious, whereas histopathology indicated comparable efficacy of Zephiran, calcium acetate, and calcium gluconate gel for all skin layers. Magnesium hydroxide antacid demonstrated efficacy only for the subdermis. The clinically beneficial effects of both Zephiran and calcium gluconate gel were affirmed. Although results suggest that calcium acetate and magnesium-containing antacids may be beneficial for human hydrofluoric acid dermal burns, these are not established clinical treatments.
在猪模型中评估了几种用于氢氟酸皮肤烧伤的局部治疗方法（洁尔灭、醋酸钙和氢氧化镁抗酸剂浸泡液以及葡萄糖酸钙凝胶）的疗效。对治疗和未治疗的烧伤部位的外观和组织病理学进行了评估。对于浅表烧伤，洁尔灭最有效；醋酸钙、氢氧化镁抗酸剂和葡萄糖酸钙凝胶效果较差。对于深度烧伤，肉眼观察表明醋酸钙和洁尔灭最有效，而组织病理学显示洁尔灭、醋酸钙和葡萄糖酸钙凝胶对所有皮肤层的疗效相当。氢氧化镁抗酸剂仅对真皮层有效。洁尔灭和葡萄糖酸钙凝胶的临床有益效果得到了证实。尽管结果表明醋酸钙和含镁抗酸剂可能对人类氢氟酸皮肤烧伤有益，但这些并非已确立的临床治疗方法。
