Long Gerald G
Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana 46256, USA.
Toxicol Pathol. 2002 Sep-Oct;30(5):592-8. doi: 10.1080/01926230290105785.
Ovaries and adjacent parovarian (mesovarial) tissues of CD-1 mice of various ages were examined to characterize cystic and proliferative epithelial lesions of the ovary and parovarian tissues. Ovaries and adjacent tissues from 6 mice each at approximately 3 and 8 months of age were processed for light microscopy and step-sections (50-micron intervals) of the entire tissue were examined. Tissues were collected from 40 mice each at 16 through 24 months of age and 3 step sections per mouse were examined. Mesonephric duct remnants were found in all mice at 3 and 8 months. Ducts were usually in the mesovarial adipose tissue and near or within the ovarian hilus and were often loosely associated with smooth muscle of the mesovarial ligament. The epithelium of the ducts varied from low cuboidal to columnar, occasional individual cells were ciliated, and small papillary configurations of epithelium were occasionally present. Ducts were dilated (> 1 mm) more often in mice at 8 months compared to 3 months, and some were continuous with cystic spaces within the ovaries. As mice aged (16-24 months), dilation and cystic change in ducts and associated compression of ovarian tissue away from the ovarian hilus became common. The epithelium of dilated ducts was generally flattened, but foci of cuboidal to columnar epithelium and/or occasional ciliated cells were present. Many ducts contained foci of hyperplastic and/or hypertrophic epithelium, and papillary projections of epithelium were occasionally found. Some of the latter lesions were consistent with a diagnosis of papillary cystadenoma. Hyperplasia of associated fibromuscular stroma was limited to a few apparently extraovarian ducts. The results of this study indicate that remnant mesonephric ductular structures are common in and adjacent to the ovaries of CD-1 mice. As mice age, these ducts become dilated and, in some, the epithelium becomes hyperplastic and/or hyperptrophic. These mesonephric duct remnants appear to be a common source of ovarian and parovarian cyts cysts and epithelial neoplasms of the ovary in mice.
对不同年龄段的CD-1小鼠的卵巢及相邻的卵巢旁（卵巢系膜）组织进行检查，以描述卵巢和卵巢旁组织的囊性和增生性上皮病变特征。分别取约3月龄和8月龄的6只小鼠的卵巢及相邻组织进行处理，制作病理切片用于光学显微镜观察，并对整个组织进行间隔50微米的连续切片检查。收集16至24月龄的40只小鼠的组织，每只小鼠检查3个连续切片。在3月龄和8月龄的所有小鼠中均发现了中肾管残余。这些管道通常位于卵巢系膜脂肪组织中，靠近卵巢门或在卵巢门内，并且常常与卵巢系膜韧带的平滑肌松散相连。管道的上皮从低立方上皮到柱状上皮不等，偶尔有单个细胞有纤毛，偶尔可见上皮的小乳头状结构。与3月龄小鼠相比，8月龄小鼠的管道扩张（直径>1毫米）更为常见，有些管道与卵巢内的囊性腔隙相连。随着小鼠年龄增长（16至24月龄），管道的扩张和囊性改变以及卵巢门以外卵巢组织的受压变得普遍。扩张管道的上皮通常扁平，但存在立方上皮到柱状上皮的灶性区域和/或偶尔的纤毛细胞。许多管道含有上皮增生和/或肥大的灶性区域，偶尔可见上皮的乳头状突起。后者中的一些病变符合乳头状囊腺瘤的诊断。相关纤维肌性间质的增生仅限于一些明显位于卵巢外的管道。本研究结果表明，中肾管残余结构在CD-1小鼠的卵巢及其附近很常见。随着小鼠年龄增长，这些管道会扩张，并且在一些小鼠中，上皮会增生和/或肥大。这些中肾管残余似乎是小鼠卵巢和卵巢旁囊肿以及卵巢上皮性肿瘤的常见来源。
