Back Thomas G, Moussa Ziad
Department of Chemistry, University of Calgary, Calgary, Alberta, Canada T2N 1N4.
J Am Chem Soc. 2002 Oct 16;124(41):12104-5. doi: 10.1021/ja028030k.
1,2-Oxaselenolane Se-oxide is a novel cyclic seleninate ester that functions as a remarkably efficient glutathione peroxidase mimetic by catalyzing the reduction of tert-butyl hydroperoxide to tert-butyl alcohol in the presence of benzyl thiol. The seleninate ester can be conveniently generated in situ by oxidation of allyl 3-hydroxypropyl selenide with tert-butyl hydroperoxide. Its catalytic activity surpasses that of several other known GPx mimetics containing cyclic selenenamide structures, which were also tested for comparison.
1,2-氧杂硒戊环硒氧化物是一种新型环状亚硒酸酯，在苄硫醇存在下，通过催化叔丁基过氧化氢还原为叔丁醇，它作为一种非常有效的谷胱甘肽过氧化物酶模拟物发挥作用。亚硒酸酯可通过用叔丁基过氧化氢氧化烯丙基3-羟丙基硒化物方便地原位生成。其催化活性超过了其他几种含环状硒代酰胺结构的已知谷胱甘肽过氧化物酶模拟物，这些模拟物也进行了比较测试。
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