硒二卤化物点击化学：炔烃的高立体选择性加成及双（-2-卤代乙烯基）硒化物谷胱甘肽过氧化物酶样活性的评价。

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of The Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russia.

Molecules. 2022 Feb 3;27(3):1050. doi: 10.3390/molecules27031050.

Highly efficient stereoselective syntheses of novel bis(-2-chlorovinyl) selenides and bis(-2-bromovinyl) selenides in quantitative yields by reactions of selenium dichloride and dibromide with alkynes were developed. The reactions proceeded at room temperature as -addition giving products exclusively with ()-stereochemistry. The glutathione peroxidase-like activity of the obtained products was estimated and compounds with high activity were found. The influence of substituents in the products on their glutathione peroxidase-like activity was discussed.

通过二氯化硒和二溴化硒与炔烃的反应，以定量产率高效立体选择性合成了新型双（-2-氯乙烯基）硒醚和双（-2-溴乙烯基）硒醚。反应在室温下进行，为 -加成，仅生成具有 ()-立体化学的产物。对所得产物的谷胱甘肽过氧化物酶样活性进行了估计，并发现了具有高活性的化合物。讨论了产物中取代基对其谷胱甘肽过氧化物酶样活性的影响。