Hagen Matthew C, Franzén Ove, McGlone Francis, Essick Greg, Dancer Christopher, Pardo José V
Cognitive Neuroimaging Unit (11P), Psychiatry Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
Eur J Neurosci. 2002 Sep;16(5):957-64. doi: 10.1046/j.1460-9568.2002.02139.x.
The human middle temporal/V5 complex (hMT/V5) plays a central role in the perception of visual motion. This region is considered a unimodal visual area with little direct involvement of other sensory modalities. The current study uses H215O PET to test whether tactile motion influences the activity of hMT/V5. Regional cerebral blood flow (rCBF) within hMT/V5 was estimated in eight subjects in separate tactile motion and visual motion conditions, each contrasted with a resting, control. The tactile motion condition involved a brush stroked proximal-to-distal along the volar forearm and palm, while the subject attended to the stimulus with closed eyes. The visual motion condition consisted of low contrast, grey-scale rings radiating at 15 degrees /s from a central point, upon which the subject was instructed to fixate. The location of hMT/V5 was defined for each subject separately as the local maximum of rCBF change during the visual motion condition (vs. control). The average change in rCBF within spherical regions of interest at each peak revealed significant bilateral activation of hMT/V5 in the tactile motion condition contrasted with a second, independent set of control scans. Additionally, a single subject received a sufficient number of scans to perform a pixel-wise, within-subject analysis. His functional images were coregistered to his anatomical MRI. In this subject, tactile motion produced a significant increase in rCBF that directly overlapped a region activated by visual motion at the posterior continuance of the inferior temporal sulcus, consistent with the known location of hMT/V5. These results suggest involvement of the hMT/V5 complex in tactile motion processing.
人类颞中回/V5复合体（hMT/V5）在视觉运动感知中起核心作用。该区域被认为是一个单峰视觉区域，很少有其他感觉模态的直接参与。本研究使用H215O正电子发射断层扫描（PET）来测试触觉运动是否会影响hMT/V5的活性。在单独的触觉运动和视觉运动条件下，对8名受试者的hMT/V5区域脑血流量（rCBF）进行了估计，每种条件均与静息对照组进行对比。触觉运动条件是用刷子沿着掌侧前臂和手掌从近端向远端抚摸，受试者闭眼关注刺激。视觉运动条件由低对比度的灰度环组成，这些环以15度/秒的速度从中心点向外辐射，受试者被指示注视这些环。分别将每个受试者的hMT/V5位置定义为视觉运动条件（与对照组相比）期间rCBF变化的局部最大值。与另一组独立的对照扫描相比，在触觉运动条件下，感兴趣的球形区域内rCBF的平均变化显示hMT/V5存在显著的双侧激活。此外，一名受试者接受了足够数量的扫描，以进行逐像素的受试者内分析。他的功能图像与他的解剖学磁共振成像（MRI）进行了配准。在该受试者中，触觉运动使rCBF显著增加，该增加直接与颞下沟后部视觉运动激活的区域重叠，这与hMT/V5的已知位置一致。这些结果表明hMT/V5复合体参与了触觉运动处理。
