Cooper S M, Wojnarowska F
Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, UK.
Clin Exp Dermatol. 2002 Sep;27(6):436-8. doi: 10.1046/j.1365-2230.2002.01069.x.
Renal transplant recipients have a greatly increased risk of nonmelanoma skin cancer. We investigated the accuracy of diagnosis of suspected skin malignancies in this population by prospectively recording all lesions detected in a specialist clinic over 5 months and comparing the provisional diagnosis with the histological diagnosis. The diagnostic accuracy was 54% in the 102 lesions that were biopsied, with the highest accuracy for the head and neck (67%). The diagnostic accuracy for squamous cell carcinoma was 48.7% (sensitivity 90.5%, specificity 75.3%) and for basal cell carcinoma 40.0% (sensitivity 66.6%, specificity 85.6%). The overall low accuracy rate implies the need for biopsy of any suspicious lesions in the renal transplant population.
肾移植受者患非黑素瘤皮肤癌的风险大幅增加。我们通过前瞻性记录在专科诊所5个月内检测到的所有病变，并将初步诊断与组织学诊断进行比较，研究了该人群中疑似皮肤恶性肿瘤的诊断准确性。在102个接受活检的病变中，诊断准确率为54%，头颈部病变的准确率最高（67%）。鳞状细胞癌的诊断准确率为48.7%（敏感性90.5%，特异性75.3%），基底细胞癌为40.0%（敏感性66.6%，特异性85.6%）。总体较低的准确率意味着肾移植人群中任何可疑病变都需要进行活检。
