Hamilton Bruce A
Department of Medicine (Division of Genetics), Department of Cellular and Molecular Medicine, and Rebecca and John Moores UCSD Cancer Center, University of California San Diego School of Medicine, La Jolla, CA 92093-0644, USA.
Genome Biol. 2002 Sep 19;3(10):reviews1029. doi: 10.1186/gb-2002-3-10-reviews1029.
How do naturally occurring polymorphisms in DNA sequence relate to variation in gene expression? Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. Other work suggests some chromosomal clustering of genes by expression pattern. A synthesis of approaches may provide new insight in to adaptive mechanisms in evolution and the population basis of complex traits.
DNA序列中的自然多态性如何与基因表达的变化相关联？最近绘制表达变异遗传来源的研究表明，顺式和反式效应之间存在惊人的平衡。其他研究表明，基因会按表达模式进行一些染色体聚类。综合各种方法可能会为进化中的适应性机制以及复杂性状的群体基础提供新的见解。
