基因变异及其在恶性肿瘤中的作用。
Genetic variation and its role in malignancy.
作者信息
Talseth-Palmer Bente A, Scott Rodney J
机构信息
School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; ; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia;
出版信息
Int J Biomed Sci. 2011 Sep;7(3):158-71.
Abstract
Genetic variation has long been thought associated with common complex disease and has therefore been widely studied. Genetic variation in the human genome is present in many forms and have been summarised in this review. The potential role of DNA damage, DNA repair and environmental influence on genetic variation in the development of cancer will be discussed, before significant genome projects are reviewed. All the various forms of genetic variation have been associated with malignancies and have been extensively studied and this is a review of the state of the field. We also discuss the road ahead in fulfilling the ultimate goal in all cancer genetic studies, which is decreasing deaths caused by cancer.
摘要
长期以来，人们一直认为基因变异与常见复杂疾病有关，因此对其进行了广泛研究。人类基因组中的基因变异有多种形式，本文对此进行了总结。在回顾重大基因组项目之前，将讨论DNA损伤、DNA修复和环境影响在癌症发生过程中对基因变异的潜在作用。所有各种形式的基因变异都与恶性肿瘤有关，并已得到广泛研究，本文将对该领域的现状进行综述。我们还将讨论在实现所有癌症基因研究的最终目标（即减少癌症导致的死亡）方面的未来之路。
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