Adair J C, Ring W H
Anesth Analg. 1975 Sep-Oct;54(5):622-5. doi: 10.1213/00000539-197509000-00015.
Because of our experience, as anesthesiologists, in the treatment of upper airway obstructions, we have been asked to see children with epiglottitis. Over a 5-year period, we have treated 28 such cases. Our hope that IPPB and nebulized racemic epinephrine would quickly relieve the obstruction, as it has in laryngotracheobronchitis, did not materialize. The obstruction from the edematous aryepiglottic folds and other hypopharyngeal structures was not relieved by such treatment, and half required an artificial airway, five by tracheal intubation. However, we documented two facts: (1) that the obstructed patient with epiglottitis can be ventilated and benefited by positive pressure by mouth or machine and that this ventilatory support can be life saving, rather than worsening the obstruction as was previously thought; (2) that with heavy-dose antibiotic-steroid therapy, the severe obstruction can be expected to improve significantly 8 to 12 hours after the onset of treatment. With this observation, we have extubated our patients at this time, rather than at 24 hours or later.
由于我们麻醉医生在上呼吸道梗阻治疗方面的经验,我们被要求诊治患有会厌炎的儿童。在5年的时间里,我们共治疗了28例此类病例。我们原本希望间歇性正压通气(IPPB)和雾化消旋肾上腺素能像在喉气管支气管炎中那样迅速缓解梗阻,但这并未实现。水肿的杓会厌襞和其他下咽结构所导致的梗阻并未因这种治疗而缓解,半数患儿需要人工气道,其中5例通过气管插管建立。然而,我们记录了两个事实:(1)患有会厌炎的梗阻患者可通过口对口或机器进行正压通气并从中获益,这种通气支持可挽救生命,而非像之前认为的那样会加重梗阻;(2)采用大剂量抗生素 - 类固醇疗法后,预计严重梗阻在治疗开始8至12小时后会显著改善。基于这一观察结果,我们此时就为患者拔除气管插管,而非在24小时或更晚的时候。