大鼠在早期发育过程中长期暴露于10 PPM氟烷的行为后果。

Behavioral consequences in rats from chronic exposure to 10 PPM halothane during early development.

作者信息

Quimby K L, Katz J, Bowman R E

出版信息

Anesth Analg. 1975 Sep-Oct;54(5):628-3. doi: 10.1213/00000539-197509000-00017.

DOI:10.1213/00000539-197509000-00017

Abstract

Albino rats were chronically exposed for 40 hours a week to 10 ppm halothane in air during early development (conception to day 60), adult life (day 60 to day 135), or both. An unexposed group served as a control. Rats exposed during early development made 30 percent more errors than rats unexposed during this period when tested on a shock-motivated visual-discrimination task, or a food-motivated spatial-discrimination task. However, the relative rate of learning was the same for all groups. Exposure during early development also lowered the jump and flinch thresholds to electric footshock as compared to animals not so treated.

摘要

在发育早期（受孕至第60天）、成年期（第60天至第135天）或两个阶段，将白化大鼠每周持续40小时暴露于空气中10 ppm的氟烷环境中。未暴露组作为对照。在电击驱动的视觉辨别任务或食物驱动的空间辨别任务测试中，发育早期暴露的大鼠比在此期间未暴露的大鼠犯错多30%。然而，所有组的相对学习速率相同。与未接受此处理的动物相比，发育早期暴露还降低了大鼠对足部电击的跳跃和退缩阈值。