Borzage Matthew Thomas, Peterson Bradley S
From the Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, California.
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.
Anesth Analg. 2025 Feb 1;140(2):409-426. doi: 10.1213/ANE.0000000000006897. Epub 2024 Mar 27.
Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in children. Many years of studies using in vitro, animal behavioral, retrospective database studies in humans, and several prospective clinical trials in humans have been invaluable in discerning the potential toxicity of anesthetics. The objective of this scoping review was to synthetize the evidence from preclinical studies for various mechanisms of toxicity across diverse experimental designs and relate their findings to those of recent clinical trials in real-world settings.
尽管麻醉能使痛苦或不适的诊断及介入性医疗程序变得可以忍受，但它也可能扰乱神经元和神经胶质细胞中的关键细胞过程，损害发育中的大脑，进而损害儿童的认知和行为。多年来，利用体外实验、动物行为学研究、人类回顾性数据库研究以及几项人类前瞻性临床试验，对于识别麻醉剂的潜在毒性非常有价值。本综述的目的是综合来自临床前研究的证据，了解不同实验设计中各种毒性机制，并将其结果与现实环境中近期临床试验的结果相关联。
