Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships.
作者信息
Sham Hing L, Zhao Chen, Li Leping, Betebenner David A, Saldivar Ayda, Vasavanonda Sudthida, Kempf Dale J, Plattner Jacob J, Norbeck Daniel W
机构信息
Pharmaceutical Discovery, R47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA.
出版信息
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3101-3. doi: 10.1016/s0960-894x(02)00643-1.
Abstract
The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1' positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.
摘要
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