Yao Jeffrey k, Stanley Jeffrey A, Reddy Ravinder D, Keshavan Matcheri S, Pettegrew Jay W
Neurochemistry and Psychopharmacology Laboratory, VA Pittsburgh Healthcare System, Building 13, 7180 Highland Drive, Pittsburgh, PA 15206, USA.
Biol Psychiatry. 2002 Oct 15;52(8):823-30. doi: 10.1016/s0006-3223(02)01397-5.
There is evidence for membrane abnormalities in schizophrenia. It is unclear whether the observed membrane deficits in peripheral cells parallel central membrane phospholipid metabolism. To address this question we examined the relations between red blood cell polyunsaturated fatty acids and brain phospholipid metabolites from different regions of interest in schizophrenia and healthy subjects.
Red blood cell membrane fatty acids were measured by capillary gas chromatography and in vivo brain phospholipid metabolite levels were measured using a multi-voxel (31)P Magnetic Resonance Spectroscopy technique on 11 first-episode, neuroleptic-naïve schizophrenic subjects and 11 normal control subjects.
Both the total polyunsaturated fatty acids and the individual 20:4(n-6) contents were significantly correlated with the freely-mobile phosphomonoester [PME(s-tau(c))] levels (r =.5643, p =.0062 and r =.6729, p =.0006, respectively). The 18:2(n-6) polyunsaturated fatty acids content correlated positively with freely-mobile phosphodiester [PDE(s-tau(c))] levels (r =.5573, p =.0071). The above correlations were present in the combined right and left prefrontal region of the brain, while other regions including the basal ganglia, occipital, inferior parietal, superior temporal and centrum semiovale yielded no significant correlations.
Our preliminary data support the association between the decreased red blood cell membrane phospholipid polyunsaturated fatty acids content and the decreased building blocks [PME(s-tau(c))] and breakdown products [PDE(s-tau(c))] of membrane phospholipids in the prefrontal region of first-episode, neuroleptic-naïve schizophrenic subjects.
有证据表明精神分裂症存在膜异常。目前尚不清楚外周细胞中观察到的膜缺陷是否与中枢膜磷脂代谢平行。为解决这个问题，我们研究了精神分裂症患者和健康受试者红细胞多不饱和脂肪酸与不同感兴趣区域脑磷脂代谢物之间的关系。
通过毛细管气相色谱法测量红细胞膜脂肪酸，并使用多体素（31）P磁共振波谱技术测量11例首发、未使用过抗精神病药物的精神分裂症患者和11例正常对照受试者的体内脑磷脂代谢物水平。
总多不饱和脂肪酸和单个20:4（n-6）含量均与自由移动的磷酸单酯[PME（s-tau（c））]水平显著相关（分别为r =.5643，p =.0062和r =.6729，p =.0006）。18:2（n-6）多不饱和脂肪酸含量与自由移动的磷酸二酯[PDE（s-tau（c））]水平呈正相关（r =.5573，p =.0071）。上述相关性存在于大脑左右前额叶联合区域，而包括基底神经节、枕叶、顶下叶、颞上叶和半卵圆中心在内的其他区域未产生显著相关性。
我们的初步数据支持首发、未使用过抗精神病药物的精神分裂症患者前额叶区域红细胞膜磷脂多不饱和脂肪酸含量降低与膜磷脂的构建块[PME（s-tau（c））]和分解产物[PDE（s-tau（c））]降低之间的关联。
