Hergueta Antonio Rodríguez, Figueira María José, López Carmen, Caamaño Olga, Fernández Franco, Rodríguez-Borges José Enrique
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Spain.
Chem Pharm Bull (Tokyo). 2002 Oct;50(10):1379-82. doi: 10.1248/cpb.50.1379.
A new and general method is described for the synthesis, in three steps and in good overall yields, of tetrasubstituted xanthines from an easily prepared imidazole precursor. The method is especially useful for the preparation in standardized conditions of series of xanthines combining a broad variety of primary or secondary alkyl, benzyl or aryl groups at N1 and of alkyl or arylmethyl groups at N3, that are not readily available by other methods.
本文描述了一种全新的通用方法，可通过三步反应以良好的总收率从易于制备的咪唑前体合成四取代黄嘌呤。该方法对于在标准化条件下制备一系列黄嘌呤尤为有用，这些黄嘌呤在N1位结合了多种伯烷基或仲烷基、苄基或芳基，在N3位结合了烷基或芳基甲基，而这些化合物通过其他方法难以获得。
