Nuesch R, Geigy N, Schaedler E, Battegay M
Outpatient Department of Internal Medicine, University Hospital, Petersgraben 4, 4031 Basel, Switzerland.
Eur J Clin Microbiol Infect Dis. 2002 Sep;21(9):684-7. doi: 10.1007/s10096-002-0792-3. Epub 2002 Sep 6.
In order to determine the impact that highly active antiretroviral therapy (HAART) has on inpatients with HIV infection, HIV-infected patients hospitalized from 1994 to 1999 at the Department of Internal Medicine, University of Basel, Switzerland, were investigated. During the observation period, 578 HIV-related hospitalizations occurred, and 502 charts from 262 different patients were available for evaluation. Analyses showed significant reductions in hospital mortality (from 13.2% to 6.5%) and length of stay for HIV-related admissions (from 16 to 11 days) in the post-HAART period, and the percentage of AIDS-related admissions decreased from 54.5% to 47.6%. However, the admission of HIV-infected patients to the intensive care unit increased from 6.3% to 11.8%, which could indicate that treating physicians have greater confidence in the outcome of HIV-infected patients due to better therapeutic options. Since the advent of HAART, the yearly number of admissions related to HIV dropped by 49% and HAART was administered often during hospital stay. By the end of the study period, death due to multiple HIV-associated diseases and wasting had disappeared.
为了确定高效抗逆转录病毒疗法（HAART）对住院的HIV感染患者的影响，我们对1994年至1999年期间在瑞士巴塞尔大学内科住院的HIV感染患者进行了调查。在观察期内，发生了578次与HIV相关的住院治疗，可获得来自262名不同患者的502份病历用于评估。分析显示，在HAART治疗后时期，医院死亡率（从13.2%降至6.5%）和与HIV相关入院的住院时间（从16天降至11天）显著降低，与艾滋病相关入院的百分比从54.5%降至47.6%。然而，HIV感染患者入住重症监护病房的比例从6.3%增加到11.8%，这可能表明由于有了更好的治疗选择，治疗医生对HIV感染患者的治疗结果更有信心。自HAART出现以来，与HIV相关的年度入院人数下降了49%，并且在住院期间经常进行HAART治疗。到研究期结束时，因多种HIV相关疾病和消瘦导致的死亡已经消失。
