Garden Jerome M, O'Banion M Kerry, Bakus Abnoeal D, Olson Carl
Department of Dermatology, Chicago, IL 60611, USA.
Arch Dermatol. 2002 Oct;138(10):1303-7. doi: 10.1001/archderm.138.10.1303.
To evaluate the possibility of disease transmission through liberated plume from virally infected tissue that is exposed to the carbon dioxide laser.
Bovine papillomavirus-induced cutaneous fibropapillomas were exposed to the carbon dioxide laser. Laser settings were within the range of clinically used settings. The laser plume (aerosol) was suctioned and collected and then reinoculated onto the skin of calves.
University laboratory research center.
Laser plume viral content and postinoculation tumor growth were analyzed and documented.
Collected laser plume contained papillomavirus DNA in all tested laser settings. The viral DNA was most likely encapsulated. Tumors developed at laser plume-inoculated sites for all laser parameter settings. Histological and biochemical analyses revealed that these tumors were infected with the same virus type as present in the laser plume.
Laser plume has been shown, for the first time to our knowledge, to actually transmit disease. Strict care must be maintained by the laser practitioner to minimize potential health risks, especially when treating viral-induced lesions or patients with viral disease.
评估通过暴露于二氧化碳激光下的病毒感染组织释放的羽状物传播疾病的可能性。
将牛乳头瘤病毒诱导的皮肤纤维乳头瘤暴露于二氧化碳激光下。激光设置在临床使用设置范围内。对激光羽状物（气溶胶）进行抽吸和收集，然后重新接种到小牛的皮肤上。
大学实验室研究中心。
分析并记录激光羽状物的病毒含量和接种后的肿瘤生长情况。
在所有测试的激光设置下，收集到的激光羽状物均含有乳头瘤病毒DNA。病毒DNA很可能被包裹起来。在所有激光参数设置下，激光羽状物接种部位均出现了肿瘤。组织学和生化分析表明，这些肿瘤感染的病毒类型与激光羽状物中存在的病毒类型相同。
据我们所知，首次证明激光羽状物确实会传播疾病。激光从业者必须严格谨慎操作，以尽量减少潜在的健康风险，尤其是在治疗病毒引起的病变或患有病毒疾病的患者时。
