Ishii Naoaki, Goto Sataro, Hartman Philip S
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Free Radic Biol Med. 2002 Oct 15;33(8):1021-5. doi: 10.1016/s0891-5849(02)00857-2.
The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function.
线虫秀丽隐杆线虫已被证明是研究衰老的强大遗传模型，包括氧化应激和蛋白质损伤的作用。在这篇综述中，我们重点关注选定的长寿（如age-1、daf-2、daf-16）和短寿（如mev-1）突变体的遗传学，这些突变体已被证明有助于揭示氧化应激、寿命和蛋白质氧化之间的关系。前者已知可控制秀丽隐杆线虫中的胰岛素/IGF-1样信号通路，而后者影响线粒体功能。
