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噬菌体(φ)C31感染天蓝色链霉菌A3(2)需要一个编码磷酸多萜醇-β-D-甘露糖合酶同源物的基因。

A gene encoding a homologue of dolichol phosphate-beta-D-mannose synthase is required for infection of Streptomyces coelicolor A3(2) by phage (phi)C31.

作者信息

Cowlishaw Deborah A, Smith Margaret C M

机构信息

Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom.

出版信息

J Bacteriol. 2002 Nov;184(21):6081-3. doi: 10.1128/JB.184.21.6081-6083.2002.

Abstract

We have shown previously that a gene encoding a homologue to the eukaryotic dolichol-phosphate-D-mannose, protein O-D-mannosyltransferase, was required for (phi)C31 infection of Streptomyces coelicolor. Here we show that a gene encoding the homologue to dolichol-phosphate-mannose synthase is also essential for phage sensitivity. These data confirm the role of glycosylation in the phage receptor for (phi)C31 in S. coelicolor.

摘要

我们之前已经表明,编码真核磷酸多萜醇 - D - 甘露糖同源物(蛋白质O - D - 甘露糖基转移酶)的基因是天蓝色链霉菌被φC31感染所必需的。在此我们表明,编码磷酸多萜醇 - 甘露糖合酶同源物的基因对于噬菌体敏感性也是必不可少的。这些数据证实了糖基化在天蓝色链霉菌中φC31噬菌体受体中的作用。

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Protein O-mannosylation.蛋白质O-甘露糖基化。
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