Chang I, Beard B
US Food and Drug Administration, 12725 Twinbrook Parkway (HFZ-133), Rockville, MD 20852, USA.
Med Eng Phys. 2002 Nov;24(9):633-40. doi: 10.1016/s1350-4533(02)00044-9.
Radiofrequency has established itself as a useful technique for managing cardiac arrhythmias and treating soft tissue tumors. However, despite its pervasive use, many of the biophysical principals needed to fully understand and optimize the radiofrequency ablation technique have not been explored. We have designed a test rig that is useful for studying the heat transfer mechanisms that affect the outcome of radiofrequency ablation devices. Using both solid and liquid phantom materials, which simulate body tissues and blood, the test rig is designed for systematic testing of the effects of predictable flow patterns on the temperature profiles generated within the solid phantom. The test rig consists of a custom built thermistor array, a linear test chamber, and a radiofrequency generator. We calibrate the flow of a liquid phantom material to demonstrate that predictable laminar flow profiles are generated. To demonstrate the performance of the ablation system, we present preliminary data attained using a commercially available cardiac ablation catheter. The advantages of this test system are its flexibility, its reproducibility, its precision, and its low cost. Thus, it is ideally suited for studying a variety of complex ablation problems involving multiple tissues types and complex blood flow geometries.
射频已成为治疗心律失常和软组织肿瘤的一项有用技术。然而，尽管其应用广泛，但许多用于全面理解和优化射频消融技术所需的生物物理原理尚未得到探索。我们设计了一种试验装置，有助于研究影响射频消融设备效果的热传递机制。该试验装置使用模拟人体组织和血液的固体和液体模型材料，用于系统测试可预测的流动模式对固体模型内产生的温度分布的影响。试验装置由定制的热敏电阻阵列、线性测试腔和射频发生器组成。我们校准液体模型材料的流动，以证明能产生可预测的层流分布。为了展示消融系统的性能，我们展示了使用市售心脏消融导管获得的初步数据。该测试系统的优点是灵活性高、可重复性强、精度高且成本低。因此，它非常适合研究涉及多种组织类型和复杂血流几何形状的各种复杂消融问题。
