Lee Tsun-Nin
Academy of Pain Research, California, San Francisco 94122, USA.
Med Hypotheses. 2002 Nov;59(5):504-21. doi: 10.1016/s0306-9877(02)00190-1.
This hypothesis proposes a mechanism by which the genetic information contained in the one-dimensional genome may be converted into a three-dimensional body plan for development. Prior to mitosis of the fertilized egg, the chromatids, after being unpackaged from the chromosomes, link up to form a giant circular loop which is then folded upon itself into a wired-frame structure that embodies the architectural embryological developmental scheme. This intranuclear spatial body design is then translated into a three-dimensional cellar plan surrounding the fertilized egg with the positional value of each surrounding daughter cell preferentially activated by specific spatially oriented gene products diffused through the neatly arranged nuclear pores of the cell nucleus of the fertilized egg. This group of cells of the primitive embryo then leads to the formation of the Spemann Organizer, which directs embryological development of the brain as well as the rest of the body. The Spemann Organizer thus retains control over the CNS which in turn controls the development and functions of the peripheral tissues. The chains of cells that compose the Spemann Organizer, forming a homunculus in the image of the wired frame formed by the chromatids are believed to be the equivalents of acupuncture meridians. To support the hypothesis, evidence is also presented to substantiate the intimate relationships between the acupuncture meridians and embryological development, evolution, the central nervous system as well as the genome. This theoretical model is capable of dispelling the mystery of acupuncture, traditional Chinese medicine and myriads of modern clinical observations, and may have the potential to usher in a multitude of innovative therapeutic methods for many difficult to treat medical conditions.
这一假说提出了一种机制，通过该机制，一维基因组中包含的遗传信息可以转化为用于发育的三维身体蓝图。在受精卵进行有丝分裂之前，染色单体从染色体上解包后，连接形成一个巨大的环状结构，然后自身折叠成一个体现胚胎发育架构方案的线框结构。这种核内空间身体设计随后被转化为围绕受精卵的三维细胞蓝图，每个周围子细胞的位置值被通过受精卵细胞核排列整齐的核孔扩散的特定空间定向基因产物优先激活。原始胚胎的这组细胞随后导致了施佩曼组织者的形成，它指导大脑以及身体其他部分的胚胎发育。施佩曼组织者因此保留对中枢神经系统的控制，而中枢神经系统又控制外周组织的发育和功能。构成施佩曼组织者的细胞链，形成了一个由染色单体形成的线框形象的侏儒，被认为等同于针灸经络。为支持这一假说，还提供了证据来证实针灸经络与胚胎发育、进化、中枢神经系统以及基因组之间的密切关系。这个理论模型能够解开针灸、传统中医以及众多现代临床观察的谜团，并且可能有潜力为许多难以治疗的病症带来大量创新的治疗方法。
