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神经科学中的蛋白质组学分析。

Proteomic analysis in the neurosciences.

作者信息

Morrison Richard S, Kinoshita Yoshito, Johnson Mark D, Uo Takuma, Ho Joseph T, McBee Joshua K, Conrads Thomas P, Veenstra Timothy D

机构信息

Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195-6470, USA.

出版信息

Mol Cell Proteomics. 2002 Aug;1(8):553-60. doi: 10.1074/mcp.r200004-mcp200.

Abstract

Proteomics is a field of study directed toward providing a comprehensive view of the characteristics and activity of every cellular protein. Rapid innovations in the core technologies required to characterize proteins on a global scale are poised to bring about a comprehensive understanding of how dynamic changes in protein expression, post-translational modification, and function affect complex signaling and regulatory networks. These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease.

摘要

蛋白质组学是一个研究领域,旨在全面了解细胞内每种蛋白质的特性和活性。在全球范围内对蛋白质进行表征所需的核心技术的快速创新,有望带来对蛋白质表达、翻译后修饰和功能的动态变化如何影响复杂信号传导和调节网络的全面理解。这些进展对于理解控制行为和认知的众多途径以及神经系统对损伤和疾病的反应具有重要意义。

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