Stevens June, Cai Jianwen, Evans Gregory W
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
Obes Res. 2002 Oct;10(10):1000-7. doi: 10.1038/oby.2002.136.
To examine associations between changes in body mass index (BMI) and changes in carotid artery intima-media thickness (IMT) in a community-based sample.
Carotid artery IMT and BMI were assessed at baseline (between 1987 and 1990) and in three subsequent examinations at 3-year intervals in participants in the Atherosclerosis Risk in Communities cohort. The 9,316 African-American and white men and women in the analysis were 45 to 64 years of age at baseline. Cross-sectional associations between BMI and IMT were assessed using general linear models. Longitudinal associations were examined using mixed models analysis.
Cross-sectional associations between BMI and IMT were confirmed. At baseline, a 1-kg/m(2) increase in BMI was associated with an increase in IMT that ranged from 2.5 to 7.5 micro m among the ethnic-gender groups examined. Changes in BMI were not associated with changes in IMT in models that adjusted for aging and other covariates. Results were similar across ethnic-gender groups.
Among free-living, 45- to 64-year-old adults, changes in common carotid artery IMT associated with changes in BMI are either very small or absent.
在一个基于社区的样本中，研究体重指数（BMI）变化与颈动脉内膜中层厚度（IMT）变化之间的关联。
在社区动脉粥样硬化风险队列研究中，于基线期（1987年至1990年之间）以及随后每3年进行的三次检查中，对参与者的颈动脉IMT和BMI进行评估。分析中的9316名非裔美国人和白人男性及女性在基线期年龄为45至64岁。使用一般线性模型评估BMI与IMT之间的横断面关联。使用混合模型分析检查纵向关联。
证实了BMI与IMT之间的横断面关联。在基线期，在所检查 的种族 - 性别组中，BMI每增加1kg/m²与IMT增加2.5至7.5微米相关。在对衰老和其他协变量进行调整的模型中，BMI的变化与IMT的变化无关。不同种族 - 性别组的结果相似。
在自由生活的45至64岁成年人中，与BMI变化相关的颈总动脉IMT变化要么非常小，要么不存在。
