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波兰首次DNA“追捕”——Y染色体短串联重复序列的应用

First Polish DNA "manhunt"--an application of Y-chromosome STRs.

作者信息

Dettlaff-Kakol A, Pawlowski R

机构信息

Institute of Forensic Medicine, Medical University of Gdansk, PL 80-210, Gdansk, Debinki 7, Poland.

出版信息

Int J Legal Med. 2002 Oct;116(5):289-91. doi: 10.1007/s00414-002-0320-0. Epub 2002 Jun 22.

DOI:10.1007/s00414-002-0320-0
PMID:12376840
Abstract

This study presents the application of Y-chromosomal STR polymorphisms to male identification in the case of a serial rapist and woman murderer in Poland. Since August 1996 a rapist from Swinoujscie (northwest Poland) committed at least 14 rapes. In the year 2000 he brutally raped 8 young girls and murdered a 22-year-old girl. DNA profiles obtained from semen stains left at the scenes of crime gave information that one and the same man had committed all the rapes. The Y-chromosome haplotype (9 loci) obtained was used for the elimination process of 421 suspects. One man was found who had an identical DNA profile in all Y-chromosome STR loci analysed and possessed common alleles in 9 out of 10 autosomal loci, strongly suggesting that the real rapist and the typed man were closely related males. Analysis of reference DNA obtained from the man's brother revealed an identical DNA STR profile to that identified at the crime scenes. To the best of our knowledge this is the first case in Poland and probably in Eastern Europe where DNA typing of a large population was used to identify the offender.

摘要

本研究介绍了Y染色体短串联重复序列(STR)多态性在波兰一名连环强奸犯兼女性谋杀犯案件中的男性身份鉴定应用。自1996年8月以来,一名来自什切青(波兰西北部)的强奸犯至少实施了14起强奸案。2000年,他残忍地强奸了8名年轻女孩并谋杀了一名22岁的女孩。从犯罪现场留下的精液污渍中获取的DNA图谱显示,所有强奸案均为同一人所为。所获得的Y染色体单倍型(9个位点)被用于421名嫌疑人的排除过程。发现一名男子在所有分析的Y染色体STR位点上具有相同的DNA图谱,并且在10个常染色体位点中的9个位点上具有共同的等位基因,这强烈表明真正的强奸犯与被检测的男子是亲缘关系密切的男性。对该男子兄弟的参考DNA进行分析后发现,其DNA STR图谱与在犯罪现场鉴定的图谱相同。据我们所知,这是波兰乃至东欧首例使用对大量人群进行DNA分型来识别罪犯的案件。

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