来自无刺帽蕊木的27-去甲三萜糖苷。

27-Nor-triterpenoid glycosides from Mitragyna inermis.

作者信息

Cheng Zhi-Hong, Yu Bo-Yang, Yang Xiu-Wei

机构信息

Department of Complex Presection of CMM, China Pharmaceutical University, 210038, Nanjing, People's Republic of China.

出版信息

Phytochemistry. 2002 Oct;61(4):379-82. doi: 10.1016/s0031-9422(02)00244-3.

DOI:10.1016/s0031-9422(02)00244-3

PMID:12377229

Abstract

From the bark of Mitragyna inermis, two 27-nor-triterpenoid glycosides, named inermiside I (1) and II (2), were isolated and their structures determined based on extensive 2D-NMR and MS spectral analysis as 6-deoxy-beta-D-glucopyranosyl-[3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]-pyrocincholate and 6-deoxy-beta-D-glucopyranosyl-pyrocincholate, respectively. In addition, the known quinovic acid (6), 3-O-[beta-D-glucopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl]-quinovoic acid (3),beta-D-glucopyranosyl-[3-O-(beta-D-glucopyranosyl)]-quinoviate (4) and cytotoxic 3-O-(beta-D-6-deoxy-glucopyranosyl)-quinovic acid (5) were also isolated.

摘要

从无刺帽蕊木的树皮中分离出两种27-降三萜糖苷，分别命名为无刺苷I（1）和II（2），并通过广泛的二维核磁共振和质谱光谱分析确定它们的结构分别为6-脱氧-β-D-吡喃葡萄糖基-[3-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基]-焦金鸡纳酸酯和6-脱氧-β-D-吡喃葡萄糖基-焦金鸡纳酸酯。此外，还分离出了已知的奎诺酸（6）、3-O-[β-D-吡喃葡萄糖基-(1→4)-α-L-鼠李吡喃糖基]-奎诺酸（3）、β-D-吡喃葡萄糖基-[3-O-(β-D-吡喃葡萄糖基)]-奎诺酸酯（4）和具有细胞毒性的3-O-(β-D-6-脱氧吡喃葡萄糖基)-奎诺酸（5）。