桔梗根中的五种新三萜皂苷。
Five new triterpenoid saponins from the roots of Platycodon grandiflorum.
作者信息
Fu Wen-Wei, Shimizu Noriko, Dou De-Qiang, Takeda Tadahiro, Fu Rui, Pei Yue-Hu, Chen Ying-Jie
机构信息
Shenyang Pharmaceutical University, School of Traditional Chinese Material Medica, Shenyang, China.
出版信息
Chem Pharm Bull (Tokyo). 2006 Apr;54(4):557-60. doi: 10.1248/cpb.54.557.
Five new triterpenoid saponins, platycoside H [3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl-2beta,3beta,16alpha,23-tetrahydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], platycoside I [3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl-2beta,3beta,16alpha,23-tetrahydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], platycoside J [3-O-beta-D-glucopyranosyl-2beta,3beta,16alpha,23-tetrahydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside], platycoside K [3-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-2beta,3beta,16alpha,23,24-pentahydroxyolean-12-en-28-oic acid], and platycoside L [3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl-2beta,3beta,16alpha,23,24-pentahydroxyolean-12-en-28 oic acid], and three known triterpenoid saponins, platycoside F, platycoside B, and platycoside C, were isolated from the roots of Platycodon grandiflorum A. DC. Their chemical structures were elucidated on the basis of their spectral data and chemical evidence.
从桔梗（Platycodon grandiflorum A. DC.）根部分离得到5个新的三萜皂苷，分别为桔梗皂苷H [3 - O - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖基 - 2β,3β,16α,23 - 四羟基齐墩果 - 12 - 烯 - 28 - 酸28 - O - β - D - 吡喃木糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→2) - α - L - 阿拉伯吡喃糖苷]、桔梗皂苷I [3 - O - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖基 - 2β,3β,16α,23 - 四羟基齐墩果 - 12 - 烯 - 2δ - 酸28 - O - β - D - 吡喃木糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→2) - α - L - 阿拉伯吡喃糖苷]、桔梗皂苷J [3 - O - β - D - 吡喃葡萄糖基 - 2β,3β,16α,23 - 四羟基齐墩果 - 12 - 烯 - 28 - 酸28 - O - β - D - 吡喃木糖基 - (1→4) - α - L - 鼠李吡喃糖基 - (1→2) - α - L - 阿拉伯吡喃糖苷]、桔梗皂苷K [3 - O - β - D - 吡喃葡萄糖基 - (1→3) - β - D - 吡喃葡萄糖基 - 2β,3β,16α,23,24 - 五羟基齐墩果 - 12 - 烯 - 28 - 酸]和桔梗皂苷L [3 - O - β - D - 吡喃葡萄糖基 - (1→6) - β - D - 吡喃葡萄糖基 - 2β,3β,16α,23,24 - 五羟基齐墩果 - 12 - 烯 - 28酸]；同时还分离得到3个已知的三萜皂苷，分别为桔梗皂苷F、桔梗皂苷B和桔梗皂苷C。根据它们的光谱数据和化学证据阐明了其化学结构。
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